Sporopollenin Exine Microcapsules as Potential Intestinal Delivery System of Probiotics

Despite several decades of research into encapsulation bacteria, most the proposed technologies are in form immobilized cultures. In this work, sporopollenin exine capsules (SECs) opened, using silica particles which act as pressing micro-probes, and loaded with Lactobacillus casei (L. casei) cells, described for first time. The provided ?30× higher yield (30.87%), compared to direct compression SECs (0.99%). Encapsulated L. cells show 1.21- 2.25-folds viability free vitro simulated fasted fed media representing human gastrointestinal (GI) tract, respectively. can proliferate inside SECs, generating enough pressure cause burst release viable metabolically active cells. noticeable difference application a means is that may bioreactor provide time encapsulated multiply thousands times before being released, following SEC's burst. unique advantages alongside method, demonstrates potential delivery system probiotics distal part GI tract.